Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study
Joint Authors
Uusitupa, Matti
Tuomainen, Tomi-Pekka
Virtanen, Jyrki K.
Voutilainen, Sari
Mursu, Jaakko
de Mello, Vanessa D. F.
Hakumäki, Martti
Pulkki, Kari
Nurmi, Tarja
Schwab, Ursula
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Epidemiological evidence suggests a role for vitamin D in type 2 diabetes prevention.
We investigated the effects of vitamin D3 supplementation on glucose metabolism and inflammation in subjects with prediabetes.
A 5-month randomized, double-blind, placebo-controlled intervention with three arms (placebo, 40 μg/d, or 80 μg/d vitamin D3) was carried out among sixty-eight overweight (BMI 25–35) and aging (≥60 years) subjects from Finland, with serum 25-hydroxyvitamin D3 [25(OH)D3] < 75 nmol/L and either impaired fasting glucose or impaired glucose tolerance.
Analyses included 66 subjects who completed the trial.
Glucose metabolism was evaluated by fasting and 2-hour oral glucose tolerance test-derived indices and glycated hemoglobin.
Inflammation was evaluated by high-sensitive C-reactive protein and five cytokines.
Although a dose-dependent increase in serum 25(OH)D3 over the supplementation period was observed (P trend < 0.001), there were no other statistically significant differences in changes in the 13 glucose homeostasis indicators between the study groups other than increase in the 120 min glucose concentration (P trend = 0.021) and a decreasing trend both in 30 min plasma insulin (P trend = 0.030) and glycated hemoglobin (P trend = 0.024) concentrations.
A borderline statistically significant decreasing trend in interleukin-1 receptor antagonist concentration was observed (P = 0.070).
Vitamin D3 supplementation does not improve glucose metabolism in ageing subjects with prediabetes but may have modest anti-inflammatory effects.
American Psychological Association (APA)
Tuomainen, Tomi-Pekka& Virtanen, Jyrki K.& Voutilainen, Sari& Nurmi, Tarja& Mursu, Jaakko& de Mello, Vanessa D. F.…[et al.]. 2015. Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067969
Modern Language Association (MLA)
Tuomainen, Tomi-Pekka…[et al.]. Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067969
American Medical Association (AMA)
Tuomainen, Tomi-Pekka& Virtanen, Jyrki K.& Voutilainen, Sari& Nurmi, Tarja& Mursu, Jaakko& de Mello, Vanessa D. F.…[et al.]. Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067969