Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats
Joint Authors
Lin, Wenting
Wang, Wenxiang
Liao, Dongdong
Chen, Damiao
Zhu, Pingping
Cai, Guoxi
Kiyoshi, Aoyagi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study investigated the effects of polysaccharides from Enteromorpha prolifera (PEP) on glucose metabolism in a rat model of diabetes mellitus (DM).
PEP (0, 150, 300, and 600 mg/kg) was administered intragastrically to rats for four weeks.
After treatment, fasting blood glucose (FBG) and insulin (INS) levels were measured, and the insulin sensitivity index (ISI) was calculated.
The morphopathological changes in the pancreas were observed.
Serum samples were collected to measure the oxidant-antioxidant status.
The mRNA expression levels of glucokinase (GCK) and insulin receptor (InsR) in liver tissue and glucose transporter type 4 (GLUT-4) and adiponectin (APN) in adipose tissue were determined.
Compared with the model group, the FBG and INS levels were lower, the ISI was higher, and the number of islet β-cells was significantly increased in all the PEP groups.
In the medium- and high-dose PEP groups, MDA levels decreased, and the enzymatic activities of SOD and GSH-Px increased.
The mRNA expression of InsR and GCK increased in all the PEP groups; APN mRNA expression increased in the high-dose PEP group, and GLUT-4 mRNA expression increased in adipose tissue.
These findings suggest that PEP is a potential therapeutic agent that can be utilized to treat DM.
American Psychological Association (APA)
Lin, Wenting& Wang, Wenxiang& Liao, Dongdong& Chen, Damiao& Zhu, Pingping& Cai, Guoxi…[et al.]. 2015. Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067973
Modern Language Association (MLA)
Lin, Wenting…[et al.]. Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats. Journal of Diabetes Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067973
American Medical Association (AMA)
Lin, Wenting& Wang, Wenxiang& Liao, Dongdong& Chen, Damiao& Zhu, Pingping& Cai, Guoxi…[et al.]. Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067973