Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
To evaluate whether insulin use was predictive for mortality from breast cancer in Taiwanese women with diabetes mellitus.
Methods.
A total of 48,880 diabetic women were followed up to determine the mortality from breast cancer during 1995–2006.
Cox models were used, considering the following independent variables: age, sex, diabetes type, diabetes duration, body mass index, smoking, insulin use, and area of residence.
Insulin use was also considered for its duration of use at cutoffs of 3 years and 5 years.
Results.
Age was a significant predictor in all analyses.
The multivariable-adjusted hazard ratio (95% confidence interval, P value) for insulin use without considering the duration of use was not statistically significant (1.339 [0.782–2.293, P = 0.2878 ]).
Compared with nonusers, insulin users showed the following adjusted hazard ratios for insulin use <3 years, ≥ 3 years, <5 years, and ≥5 years: 0.567 (0.179–1.791, P = 0.3333 ), 2.006 (1.102–3.653, P = 0.0228 ), 1.045 (0.505–2.162, P = 0.9048 ), and 1.899 (0.934–3.860, P = 0.0763 ).
Conclusions.
Insulin use (mainly human insulin) for ≥3 years may be associated with a higher risk of breast cancer mortality.
American Psychological Association (APA)
Tseng, Chin-Hsiao. 2015. Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067974
Modern Language Association (MLA)
Tseng, Chin-Hsiao. Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067974
American Medical Association (AMA)
Tseng, Chin-Hsiao. Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067974