Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA
Joint Authors
Lipner, Ettie M.
Tomer, Yaron
Monti, Maria C.
Lonsdale, John T.
Corso, Barbara
Greenberg, David A.
Noble, Janelle A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We conducted linkage analysis to follow up earlier work on microvascular complications of type 1 diabetes (T1D).
We analyzed 415 families (2,008 individuals) previously genotyped for 402 SNP markers spanning chromosome 6.
We did linkage analysis for the phenotypes of retinopathy and nephropathy.
For retinopathy, two linkage peaks were mapped: one located at the HLA region and another novel locus telomeric to HLA.
For nephropathy, a linkage peak centromeric to HLA was mapped, but the linkage peak telomeric to HLA seen in retinopathy was absent.
Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stratified our analyses based on families whose probands were positive for DRB1*03:01 or DRB1*04:01.
When analyzing the DRB1*03:01-positive retinopathy families, in addition to the novel telomeric locus, one centromeric to HLA was identified at the same location as the nephropathy peak.
When we stratified on DRB1*04:01-positive families, the HLA telomeric peak strengthened but the centromeric peak disappeared.
Our findings showed that HLA and non-HLA loci on chromosome 6 are involved in T1D complications’ expression.
While the HLA region is a major contributor to the expression of T1D, our results suggest an interaction between specific HLA alleles and other loci that influence complications’ expression.
American Psychological Association (APA)
Lipner, Ettie M.& Tomer, Yaron& Noble, Janelle A.& Monti, Maria C.& Lonsdale, John T.& Corso, Barbara…[et al.]. 2015. Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067977
Modern Language Association (MLA)
Lipner, Ettie M.…[et al.]. Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067977
American Medical Association (AMA)
Lipner, Ettie M.& Tomer, Yaron& Noble, Janelle A.& Monti, Maria C.& Lonsdale, John T.& Corso, Barbara…[et al.]. Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067977