Liraglutide, a Glucagon-Like Peptide-1 Analog, Increased Insulin Sensitivity Assessed by Hyperinsulinemic-Euglycemic Clamp Examination in Patients with Uncontrolled Type 2 Diabetes Mellitus
Joint Authors
Jinnouchi, Hideaki
Sugiyama, Seigo
Yoshida, Akira
Hieshima, Kunio
Kurinami, Noboru
Suzuki, Tomoko
Miyamoto, Fumio
Kajiwara, Keizo
Matsui, Kunihiko
Jinnouchi, Tomio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
Glucagon-like peptide-1 (GLP-1) analog promotes insulin secretion by acting on pancreatic β-cells.
This antihyperglycemic treatment for type 2 diabetes mellitus (DM) has attracted increased clinical attention not only for its antihyperglycemic action but also for its potential extrapancreatic effects.
We investigated whether liraglutide, a GLP-1 analog, could enhance insulin sensitivity as assessed by the hyperinsulinemic-euglycemic clamp in type 2 DM patients.
Materials.
We prospectively enrolled 31 uncontrolled type 2 DM patients who were hospitalized and equally managed by guided diet- and exercise-therapies and then introduced to either liraglutide- or intensive insulin-therapy for 4 weeks.
Insulin sensitivity was assessed by the glucose infusion rate (GIR) using hyperinsulinemic-euglycemic clamp before and after the therapies.
Results.
Values of HbA1c, postprandial plasma glucose, and body mass index (BMI) were significantly decreased by hospitalized intensive insulin-therapy or liraglutide-therapy.
GIR was significantly increased by liraglutide-therapy but not by insulin-therapy, indicating that liraglutide-therapy significantly enhanced insulin sensitivity.
BMI decreased during liraglutide-therapy but was not significantly correlated with changes in GIR.
Multivariate logistic regression analysis demonstrated that liraglutide-therapy significantly correlated with increased insulin sensitivity in uncontrolled DM patients.
Conclusions.
Liraglutide may exhibit favorable effects on diabetes control for type 2 DM patients by increasing insulin sensitivity as an extrapancreatic action.
Clinical trial registration Unique Identifier is UMIN000015201.
American Psychological Association (APA)
Jinnouchi, Hideaki& Sugiyama, Seigo& Yoshida, Akira& Hieshima, Kunio& Kurinami, Noboru& Suzuki, Tomoko…[et al.]. 2015. Liraglutide, a Glucagon-Like Peptide-1 Analog, Increased Insulin Sensitivity Assessed by Hyperinsulinemic-Euglycemic Clamp Examination in Patients with Uncontrolled Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067981
Modern Language Association (MLA)
Jinnouchi, Hideaki…[et al.]. Liraglutide, a Glucagon-Like Peptide-1 Analog, Increased Insulin Sensitivity Assessed by Hyperinsulinemic-Euglycemic Clamp Examination in Patients with Uncontrolled Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067981
American Medical Association (AMA)
Jinnouchi, Hideaki& Sugiyama, Seigo& Yoshida, Akira& Hieshima, Kunio& Kurinami, Noboru& Suzuki, Tomoko…[et al.]. Liraglutide, a Glucagon-Like Peptide-1 Analog, Increased Insulin Sensitivity Assessed by Hyperinsulinemic-Euglycemic Clamp Examination in Patients with Uncontrolled Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067981