![](/images/graphics-bg.png)
Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice
Joint Authors
Chen, Wei-Hong
Chuu, Jiunn-Jye
Yu, Sung-Hsun
Chen, Szu-Yu Tina
Li, Wei-Shan
Dubey, Navneet Kumar
Deng, Win-Ping
Leu, Sy-Jye
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion.
Hypoglycemic medications for type 2 DM have either proven inadequate or posed adverse effects; therefore, the Chinese herbal products are under investigation as an alternative treatment.
In this study, a novel combination of fruiting body and mycelia powder of herbal Cordyceps militaris number 1 (CmNo1) was administered to evaluate their potential hypoglycemic effects in high-fat diet- (HFD-) induced type 2 DM in C57BL/6J mice.
Body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), and blood biochemistry indexes were measured.
Results indicated that CmNo1 lowered the blood glucose level by increasing insulin sensitivity, while no change in body weight was observed.
Increased protein expression of IRS-1, pIRS-1, AKT, pAKT, and GLUT-4 in skeletal muscle and adipose tissue was found indicating restoration of insulin signaling.
Additionally, PPAR-γ expression in adipose tissue restored the triglyceride and cholesterol levels.
Finally, our results suggest that CmNo1 possesses strong hypoglycemic, anticholesterolemic, and antihypertriglyceridemic actions and is more economical alternate for DM treatment.
American Psychological Association (APA)
Yu, Sung-Hsun& Chen, Szu-Yu Tina& Li, Wei-Shan& Dubey, Navneet Kumar& Chen, Wei-Hong& Chuu, Jiunn-Jye…[et al.]. 2015. Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067982
Modern Language Association (MLA)
Yu, Sung-Hsun…[et al.]. Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067982
American Medical Association (AMA)
Yu, Sung-Hsun& Chen, Szu-Yu Tina& Li, Wei-Shan& Dubey, Navneet Kumar& Chen, Wei-Hong& Chuu, Jiunn-Jye…[et al.]. Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067982