The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy
Joint Authors
Rojewska, Ewelina
Mika, Joanna
Zychowska, Magdalena
Pilat, Dominika
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The mechanism involved in the development of diabetic neuropathy is complex.
Currently, it is thought that chemokines play an important role in this process.
The aim of this study was to determine how the level of some chemokines from the CXC subfamily varies in diabetic neuropathy and how the chemokines affect nociceptive transmission.
A single intraperitoneal (i.p.) injection of streptozotocin (STZ; 200 mg/kg) resulted in an increased plasma glucose.
The development of allodynia and hyperalgesia was measured at day 7 after STZ administration.
Using Antibody Array techniques, the increases in CXCL1 (KC), CXCL5 (LIX), CXCL9 (MIG), and CXCL12 (SDF-1) protein levels were detected in STZ-injected mice.
No changes in CXCL11 (I-TAC) or CXCL13 (BLC) protein levels were observed.
The single intrathecal (i.t.) administration of CXCL1, CXCL5, CXCL9, and CXCL12 (each in doses of 10, 100, and 500 ng/5 μL) shows their pronociceptive properties as measured 1, 4, and 24 hours after injection using the tail-flick, von Frey, and cold plate tests.
These findings indicate that the chemokines CXCL1, CXCL5, CXCL9, and CXCL12 are important in nociceptive transmission and may play a role in the development of diabetic neuropathy.
American Psychological Association (APA)
Zychowska, Magdalena& Rojewska, Ewelina& Pilat, Dominika& Mika, Joanna. 2015. The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1067992
Modern Language Association (MLA)
Zychowska, Magdalena…[et al.]. The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy. Journal of Diabetes Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1067992
American Medical Association (AMA)
Zychowska, Magdalena& Rojewska, Ewelina& Pilat, Dominika& Mika, Joanna. The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1067992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067992