Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection
Joint Authors
Toledo, Alexandra
Velasco, Manuel
Cabrera, Mayela
Cano, Climaco
Salazar, Juan
Apruzzese, Vanessa
González, Robys
López-Miranda, José
Bermúdez, Valmore
Bello, Luis
Áñez, Roberto
Rojas, Joselyn
Chacín, Maricarmen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Introduction.
The purpose of this study was to analyze the influence of metabolic phenotypes during the construction of ROC curves for waist circumference (WC) cutpoint selection.
Materials and Methods.
A total of 1,902 subjects of both genders were selected from the Maracaibo City Metabolic Syndrome Prevalence Study database.
Two-Step Cluster Analysis (TSCA) was applied to select metabolically healthy and sick men and women.
ROC curves were constructed to determine WC cutoff points by gender.
Results.
Through TSCA, metabolic phenotype predictive variables were selected: HOMA2-IR and HOMA2-βcell for women and HOMA2-IR, HOMA2-βcell, and TAG for men.
Subjects were classified as healthy normal weight, metabolically obese normal weight, healthy and metabolically disturbed overweight, and healthy and metabolically disturbed obese.
Final WC cutpoints were 91.50 cm for women (93.4% sensitivity, 93.7% specificity) and 98.15 cm for men (96% sensitivity, 99.5% specificity).
Conclusions.
TSCA in the selection of the groups used in ROC curves construction proved to be an important tool, aiding in the detection of MOWN and MHO which cannot be identified with WC alone.
The resulting WC cutpoints were <91.00 cm for women and <98.00 cm for men.
Furthermore, anthropometry is insufficient to determine healthiness, and, biochemical analysis is needed to properly filter subjects during classification.
American Psychological Association (APA)
Bermúdez, Valmore& Rojas, Joselyn& Salazar, Juan& Áñez, Roberto& Toledo, Alexandra& Bello, Luis…[et al.]. 2015. Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067993
Modern Language Association (MLA)
Bermúdez, Valmore…[et al.]. Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection. Journal of Diabetes Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1067993
American Medical Association (AMA)
Bermúdez, Valmore& Rojas, Joselyn& Salazar, Juan& Áñez, Roberto& Toledo, Alexandra& Bello, Luis…[et al.]. Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067993