Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22
Joint Authors
Matsumoto, Kozo
Kose, Hiroyuki
Yamada, Takahisa
Kawasaki, Kurenai
Yamada, Sawaka
Ogata, Koki
Saito, Yumiko
Takahama, Aiko
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Type 2 diabetes (T2D) is one of the most common human diseases.
QTL analysis of the diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats has identified numerous hyperglycemic loci.
However, molecular characterization and/or gene identification largely remains to be elucidated due mostly to the weak genetic variances contributed by each locus.
Here we utilized Drosophila melanogaster as a secondary model organism for functional evaluation of the candidate gene.
We demonstrate that the tissue specific knockdown of a homologue of igf2bp2 RNA binding protein leads to increased sugar levels similar to that found in the OLETF rat.
In the mutant, the expression of two of the insulin-like peptides encoded in the fly genome, dilp2 and dilp3, were found to be downregulated.
Consistent with previous reports of dilp mutants, the imp mutant flies exhibited an extension of life span; in contrast, starvation tolerance was reduced.
These results further reinforce the possibility that imp is involved in sugar metabolism by modulating insulin expression.
American Psychological Association (APA)
Kawasaki, Kurenai& Yamada, Sawaka& Ogata, Koki& Saito, Yumiko& Takahama, Aiko& Yamada, Takahisa…[et al.]. 2015. Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067995
Modern Language Association (MLA)
Kawasaki, Kurenai…[et al.]. Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067995
American Medical Association (AMA)
Kawasaki, Kurenai& Yamada, Sawaka& Ogata, Koki& Saito, Yumiko& Takahama, Aiko& Yamada, Takahisa…[et al.]. Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067995