Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats
Joint Authors
Chan, Kim Wei
Imam, Mustapha Umar
Azmi, Nur Hanisah
Ismail, Maznah
Yida, Zhang
Ooi, Der-Jiun
Sarega, Nadarajan
Hou, Zhiping
Yusuf, Norhayati Binti
Ismail, Norsharina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Edible bird’s nest (EBN) is used traditionally in many parts of Asia to improve wellbeing, but there are limited studies on its efficacy.
We explored the potential use of EBN for prevention of high fat diet- (HFD-) induced insulin resistance in rats.
HFD was given to rats with or without simvastatin or EBN for 12 weeks.
During the intervention period, weight measurements were recorded weekly.
Blood samples were collected at the end of the intervention and oral glucose tolerance test conducted, after which the rats were sacrificed and their liver and adipose tissues collected for further studies.
Serum adiponectin, leptin, F2-isoprostane, insulin, and lipid profile were estimated, and homeostatic model assessment of insulin resistance computed.
Effects of the different interventions on transcriptional regulation of insulin signaling genes were also evaluated.
The results showed that HFD worsened metabolic indices and induced insulin resistance partly through transcriptional regulation of the insulin signaling genes.
Additionally, simvastatin was able to prevent hypercholesterolemia but promoted insulin resistance similar to HFD.
EBN, on the other hand, prevented the worsening of metabolic indices and transcriptional changes in insulin signaling genes due to HFD.
The results suggest that EBN may be used as functional food to prevent insulin resistance.
American Psychological Association (APA)
Yida, Zhang& Imam, Mustapha Umar& Ismail, Maznah& Ooi, Der-Jiun& Sarega, Nadarajan& Azmi, Nur Hanisah…[et al.]. 2015. Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067996
Modern Language Association (MLA)
Yida, Zhang…[et al.]. Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067996
American Medical Association (AMA)
Yida, Zhang& Imam, Mustapha Umar& Ismail, Maznah& Ooi, Der-Jiun& Sarega, Nadarajan& Azmi, Nur Hanisah…[et al.]. Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067996