Comment on “Renal Protective Effect of Sirtuin 1”
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-1, 1 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-20
Country of Publication
Egypt
No. of Pages
1
Main Subjects
Abstract EN
I read the review article written by Dong et al.
[1] regarding the renal effects of sirtuin 1 with great interest.
The authors described the harmful effects of advanced glycation end products on podocyte apoptosis via increasing Bcl-2 protein secondary to forkhead box O4 (FOXO4) acetylation in diabetes mellitus according to Chung et al.’ findings.
However, Chuang et al.
[2] demonstrated that the apoptosis of podocyte was associated with the expression of a proapoptosis gene, Bcl-2-like 11 (Bcl2l11), not antiapoptotic Bcl-2.
To date, a total of 25 Bcl-2 related genes have been identified.
Among them, Bcl-2, Bcl-xL, and Bcl-w are antiapoptotic; however, BAD, Bax, Bak, and Bcl2l11 are proapoptotic [3].
Hence, researchers should consider this important knowledge to avoid misunderstanding.
American Psychological Association (APA)
Turkmen, Kultigin. 2015. Comment on “Renal Protective Effect of Sirtuin 1”. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-1.
https://search.emarefa.net/detail/BIM-1067997
Modern Language Association (MLA)
Turkmen, Kultigin. Comment on “Renal Protective Effect of Sirtuin 1”. Journal of Diabetes Research No. 2015 (2015), pp.1-1.
https://search.emarefa.net/detail/BIM-1067997
American Medical Association (AMA)
Turkmen, Kultigin. Comment on “Renal Protective Effect of Sirtuin 1”. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-1.
https://search.emarefa.net/detail/BIM-1067997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067997