Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge
Joint Authors
Adams-Huet, Beverley
Pillai, Anil Kumar
Silvers, William
Christensen, Preston
Riegel, Matthew
Lingvay, Ildiko
Sun, Xiankai
Öz, Orhan K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Advances in noninvasive imaging modalities have provided opportunities to study β cell function through imaging zinc release from insulin secreting β cells.
Understanding the temporal secretory pattern of insulin and zinc corelease after a glucose challenge is essential for proper timing of administration of zinc sensing probes.
Portal venous sampling is an essential part of pharmacological and nutritional studies in animal models.
The purpose of this study was to compare two different percutaneous image-guided techniques: transhepatic ultrasound guided portal vein access and transsplenic fluoroscopy guided splenic vein access for ease of access, safety, and evaluation of temporal kinetics of insulin and zinc release into the venous effluent from the pancreas.
Both techniques were safe, reproducible, and easy to perform.
The mean time required to obtain desired catheter position for venous sampling was 15 minutes shorter using the transsplenic technique.
A clear biphasic insulin release profile was observed in both techniques.
Statistically higher insulin concentration but similar zinc release after a glucose challenge was observed from splenic vein samples, as compared to the ones from the portal vein.
To our knowledge, this is the first report of percutaneous methods to assess zinc release kinetics from the porcine pancreas.
American Psychological Association (APA)
Pillai, Anil Kumar& Silvers, William& Christensen, Preston& Riegel, Matthew& Adams-Huet, Beverley& Lingvay, Ildiko…[et al.]. 2015. Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067999
Modern Language Association (MLA)
Pillai, Anil Kumar…[et al.]. Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067999
American Medical Association (AMA)
Pillai, Anil Kumar& Silvers, William& Christensen, Preston& Riegel, Matthew& Adams-Huet, Beverley& Lingvay, Ildiko…[et al.]. Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067999