A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice
Joint Authors
Shao, Xinyu
Chen, Yunya
Wang, Xiujie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type II diabetes mellitus (T2D) is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action.
The deficit and dysfunction of insulin secreting β-cell are signature symptom for T2D.
Additionally, in pancreatic β-cell, a small group of genes which are abundantly expressed in most other tissues are highly selectively repressed.
Lactate dehydrogenase A (LDHA) is one of such genes.
Upregulation of LDHA is found in both human T2D and rodent T2D models.
In this study, we identified a LDHA-suppressing microRNA (hsa-miR-590-3p) and used it together with human embryonic stem cell (hESC) derived pancreatic endoderm (PE) transplantation into a high-fat diet induced T2D mouse model.
The procedure significantly improved glucose metabolism and other symptoms of T2D.
Our findings support the potential T2D treatment using the combination of microRNA and hESC-differentiated PE cells.
American Psychological Association (APA)
Chen, Yunya& Wang, Xiujie& Shao, Xinyu. 2015. A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068002
Modern Language Association (MLA)
Chen, Yunya…[et al.]. A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068002
American Medical Association (AMA)
Chen, Yunya& Wang, Xiujie& Shao, Xinyu. A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068002