The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class?
Joint Authors
Teixeira, Frederico
Mega, Cristina
Teixeira de Lemos, Edite
Fernandes, Rosa
Godinho, Ricardo
Carvalho, Eugénia
Reis, Flávio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Abstract EN
Incretin-based therapies, the most recent therapeutic options for type 2 diabetes mellitus (T2DM) management, can modify various elements of the disease, including hypersecretion of glucagon, abnormal gastric emptying, postprandial hyperglycaemia, and, possibly, pancreatic β cell dysfunction.
Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) increase glucagon-like peptide-1 (GLP-1) availability and correct the “incretin defect” seen in T2DM patients.
Clinical studies have shown good glycaemic control with minimal risk of hypoglycaemia or any other adverse effects, despite the reports of pancreatitis, whose association remains to be proved.
Recent studies have been focusing on the putative ability of DPP-4 inhibitors to preserve pancreas function, in particular due to the inhibition of apoptotic pathways and stimulation of β cell proliferation.
In addition, other cytoprotective effects on other organs/tissues that are involved in serious T2DM complications, including the heart, kidney, and retina, have been increasingly reported.
This review outlines the therapeutic potential of DPP-4 inhibitors for the treatment of T2DM, focusing on their main features, clinical applications, and risks, and discusses the major challenges for the future, in particular the possibility of becoming the preferred therapy for T2DM due to their ability to modify the natural history of the disease and ameliorate nephropathy, retinopathy, and cardiovascular complications.
American Psychological Association (APA)
Godinho, Ricardo& Mega, Cristina& Teixeira de Lemos, Edite& Carvalho, Eugénia& Teixeira, Frederico& Fernandes, Rosa…[et al.]. 2015. The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class?. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-28.
https://search.emarefa.net/detail/BIM-1068007
Modern Language Association (MLA)
Godinho, Ricardo…[et al.]. The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class?. Journal of Diabetes Research No. 2015 (2015), pp.1-28.
https://search.emarefa.net/detail/BIM-1068007
American Medical Association (AMA)
Godinho, Ricardo& Mega, Cristina& Teixeira de Lemos, Edite& Carvalho, Eugénia& Teixeira, Frederico& Fernandes, Rosa…[et al.]. The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class?. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-28.
https://search.emarefa.net/detail/BIM-1068007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068007