KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus
Joint Authors
Haerian, Batoul Sadat
Abdullah, Nor Azizan
Mohamed, Zahurin
Haghvirdizadeh, Polin
Haghvirdizadeh, Pantea
Haerian, Monir Sadat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century.
It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia.
Of the various types of DM, type 2 occurs most frequently.
Multiple genes and their interactions are involved in the insulin secretion pathway.
Insulin secretion is mediated through the ATP-sensitive potassium (KATP) channel in pancreatic beta cells.
This channel is a heteromeric protein, composed of four inward-rectifier potassium ion channel (Kir6.2) tetramers, which form the pore of the KATP channel, as well as sulfonylurea receptor 1 subunits surrounding the pore.
Kir6.2 is encoded by the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) gene, a member of the potassium channel genes.
Numerous studies have reported the involvement of single nucleotide polymorphisms of the KCNJ11 gene and their interactions in the susceptibility to DM.
This review discusses the current evidence for the contribution of common KCNJ11 genetic variants to the development of DM.
Future studies should concentrate on understanding the exact role played by these risk variants in the development of DM.
American Psychological Association (APA)
Haghvirdizadeh, Polin& Mohamed, Zahurin& Abdullah, Nor Azizan& Haghvirdizadeh, Pantea& Haerian, Monir Sadat& Haerian, Batoul Sadat. 2015. KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068022
Modern Language Association (MLA)
Haghvirdizadeh, Polin…[et al.]. KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068022
American Medical Association (AMA)
Haghvirdizadeh, Polin& Mohamed, Zahurin& Abdullah, Nor Azizan& Haghvirdizadeh, Pantea& Haerian, Monir Sadat& Haerian, Batoul Sadat. KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068022