On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides
Joint Authors
Tomasello, Marianna Flora
Sinopoli, Alessandro
Pappalardo, Giuseppe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Pancreatic islets in type 2 diabetes mellitus (T2DM) patients are characterized by reduced β-cells mass and diffuse extracellular amyloidosis.
Amyloid deposition involves the islet amyloid polypeptide (IAPP), a neuropancreatic hormone cosecreted with insulin by β-cells.
IAPP is physiologically involved in glucose homeostasis, but it may turn toxic to β-cells owing to its tendency to misfold giving rise to oligomers and fibrils.
The process by which the unfolded IAPP starts to self-assemble and the overall factors promoting this conversion are poorly understood.
Other open questions are related to the nature of the IAPP toxic species and how exactly β-cells die.
Over the last decades, there has been growing consensus about the notion that early molecular assemblies, notably small hIAPP oligomers, are the culprit of β-cells decline.
Numerous environmental factors might affect the conformational, aggregation, and cytotoxic properties of IAPP.
Herein we review recent progress in the field, focusing on the influences that membranes, pH, and metal ions may have on the conformational conversion and cytotoxicity of full-length IAPP as well as peptide fragments thereof.
Current theories proposed for the mechanisms of toxicity will be also summarized together with an outline of the underlying molecular links between IAPP and amyloid beta (Aβ) misfolding.
American Psychological Association (APA)
Tomasello, Marianna Flora& Sinopoli, Alessandro& Pappalardo, Giuseppe. 2015. On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068028
Modern Language Association (MLA)
Tomasello, Marianna Flora…[et al.]. On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides. Journal of Diabetes Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068028
American Medical Association (AMA)
Tomasello, Marianna Flora& Sinopoli, Alessandro& Pappalardo, Giuseppe. On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068028