The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers
Joint Authors
Liu, Guanjian
Wang, Chun
Li, Lan
Chen, Dawei
Ran, Xingwu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To investigate the dynamic changes on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in the diabetic chronic refractory cutaneous ulcers after the autologous platelet-rich gel (APG) treatment.
Methods.
The study was developed at the Diabetic Foot Care Centre, West China Hospital.
The granulation tissues from the target wounds were taken before and within 15 days after APG application.
The expression of MMP-2 and TIMP-2 as well as transforming growth factor-β1 (TGF-β1) in the granulation tissue was detected by q TR-PCR and IHC.
The relationship between the expression level of MMP-2 and TIMP-2 and their ratio and that of TGF-β1 was analyzed.
Results.
The expression of MMP-2 (P < 0.05) was suppressed, and the expression of TIMP-2 (P < 0.05) was promoted, while the ratio of MMP-2/TIMP-2 (P < 0.05) was decreased after APG treatments.
The expression of TGF-β1 had negative correlation with the ratio of MMP-2/TIMP-2 (P < 0.05) and positive correlation with the expression of TIMP-2 (P < 0.05).
Conclusions.
APG treatment may suppress the expression of MMP-2, promoting that of the TIMP-2 in the diabetic chronic refractory cutaneous wounds.
TGF-β1 may be related to these effects.
American Psychological Association (APA)
Li, Lan& Chen, Dawei& Wang, Chun& Liu, Guanjian& Ran, Xingwu. 2015. The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068037
Modern Language Association (MLA)
Li, Lan…[et al.]. The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers. Journal of Diabetes Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068037
American Medical Association (AMA)
Li, Lan& Chen, Dawei& Wang, Chun& Liu, Guanjian& Ran, Xingwu. The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068037