Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice
Joint Authors
Alkan, Manal
Machavoine, François
Rignault, Rachel
Dam, Julie
Thieblemont, Nathalie
Dy, Michel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent evidence has highlighted the role of histamine in inflammation.
Since this monoamine has also been strongly implicated in the pathogenesis of type-1 diabetes, we assessed its effect in the nonobese diabetic (NOD) mouse model.
To this end, we used mice (inactivated) knocked out for the gene encoding histidine decarboxylase, the unique histamine-forming enzyme, backcrossed on a NOD genetic background.
We found that the lack of endogenous histamine in NOD HDC−/− mice decreased the incidence of diabetes in relation to their wild-type counterpart.
Whereas the proportion of regulatory T and myeloid-derived suppressive cells was similar in both strains, histamine deficiency was associated with increased levels of immature macrophages, as compared with wild-type NOD mice.
Concerning the cytokine pattern, we found a decrease in circulating IL-12 and IFN-γ in HDC−/− mice, while IL-6 or leptin remained unchanged, suggesting that histamine primarily modulates the inflammatory environment.
Paradoxically, exogenous histamine given to NOD HDC−/− mice provided also protection against T1D.
Our study supports the notion that histamine is involved in the pathogenesis of diabetes, thus providing additional evidence for its role in the regulation of the immune response.
American Psychological Association (APA)
Alkan, Manal& Machavoine, François& Rignault, Rachel& Dam, Julie& Dy, Michel& Thieblemont, Nathalie. 2015. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068042
Modern Language Association (MLA)
Alkan, Manal…[et al.]. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068042
American Medical Association (AMA)
Alkan, Manal& Machavoine, François& Rignault, Rachel& Dam, Julie& Dy, Michel& Thieblemont, Nathalie. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068042