Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes
Joint Authors
Isibasi, Armando
Molina-Ayala, Mario
Ramírez-Rentería, Claudia
Ferreira-Hermosillo, Aldo
Vargas, Guadalupe
Gonzalez, Baldomero
Mendoza, Victoria
Archundia-Riveros, Irma
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups.
Design.
We conducted a cross-sectional evaluation of all patients in our type 1 diabetes clinic from January 2012 to January 2013.
Patients were considered to have metabolic syndrome when they fulfilled the joint statement criteria and were evaluated for clinical, biochemical, and immunological features.
Methods.
We determined serum IL-6, IL-8, IL-10, and TNF with flow cytometry and adiponectin and resistin concentrations with enzyme linked immunosorbent assay in patients with and without metabolic syndrome.
We also compared estimated glucose disposal rate between groups.
Results.
We tested 140 patients.
Forty-four percent fulfilled the metabolic syndrome criteria (n=61), 54% had central obesity, 30% had hypertriglyceridemia, 29% had hypoalphalipoproteinemia, and 19% had hypertension.
We observed that resistin concentrations were higher in patients with MS.
Conclusion.
We found a high prevalence of MS in Mexican patients with T1D.
The increased level of resistin may be related to the increased fat mass and could be involved in the development of insulin resistance.
American Psychological Association (APA)
Ferreira-Hermosillo, Aldo& Molina-Ayala, Mario& Ramírez-Rentería, Claudia& Vargas, Guadalupe& Gonzalez, Baldomero& Isibasi, Armando…[et al.]. 2015. Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068044
Modern Language Association (MLA)
Ferreira-Hermosillo, Aldo…[et al.]. Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068044
American Medical Association (AMA)
Ferreira-Hermosillo, Aldo& Molina-Ayala, Mario& Ramírez-Rentería, Claudia& Vargas, Guadalupe& Gonzalez, Baldomero& Isibasi, Armando…[et al.]. Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068044