Patterns of Exposure to Multiple Metals and Associations with Neurodevelopment of Preschool Children from Montevideo, Uruguay
Joint Authors
Ettinger, Adrienne S.
Kordas, Katarzyna
Ardoino, Graciela
Queirolo, Elena I.
Ciccariello, Daniela
Mañay, Nelly
Coffman, Donna
Source
Journal of Environmental and Public Health
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
While it is known that toxic metals contribute individually to child cognitive and behavioral deficits, we still know little about the effects of exposure to multiple metals, particularly when exposures are low.
We studied the association between children’s blood lead and hair arsenic, cadmium, and manganese and their performance on the Bayley Scales of Infant Development III.
Ninety-two preschool children (age 13–42 months) from Montevideo, Uruguay, provided a hair sample and 78 had a blood lead level (BLL) measurement.
Using latent class analysis (LCA), we identified four groups of exposure based on metal concentrations: (1) low metals, (2) low-to-moderate metals, (3) high lead and cadmium, and (4) high metals.
Using the four-group exposure variable as the main predictor, and fitting raw scores on the cognitive, receptive vocabulary, and expressive vocabulary scales as dependent variables, both complete-case and multiple imputation (MI) analyses were conducted.
We found no association between multiple-metal exposures and neurodevelopment in covariate-adjusted models.
This study demonstrates the use of LCA together with MI to determine patterns of exposure to multiple toxic metals and relate these to child neurodevelopment.
However, because the overall study population was small, other studies with larger sample sizes are needed to investigate these associations.
American Psychological Association (APA)
Kordas, Katarzyna& Ardoino, Graciela& Coffman, Donna& Queirolo, Elena I.& Ciccariello, Daniela& Mañay, Nelly…[et al.]. 2015. Patterns of Exposure to Multiple Metals and Associations with Neurodevelopment of Preschool Children from Montevideo, Uruguay. Journal of Environmental and Public Health،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068190
Modern Language Association (MLA)
Kordas, Katarzyna…[et al.]. Patterns of Exposure to Multiple Metals and Associations with Neurodevelopment of Preschool Children from Montevideo, Uruguay. Journal of Environmental and Public Health No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068190
American Medical Association (AMA)
Kordas, Katarzyna& Ardoino, Graciela& Coffman, Donna& Queirolo, Elena I.& Ciccariello, Daniela& Mañay, Nelly…[et al.]. Patterns of Exposure to Multiple Metals and Associations with Neurodevelopment of Preschool Children from Montevideo, Uruguay. Journal of Environmental and Public Health. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068190