Lactic Acid Bacteria Strains Exert Immunostimulatory Effect on H. pylori-Induced Dendritic Cells
Joint Authors
Eljaszewicz, Andrzej
Helmin-Basa, Anna
Gackowska, Lidia
Wiese, Małgorzata
Andryszczyk, Marek
Motyl, Ilona
Wieczyńska, Jolanta
Januszewska, Milena
Michalkiewicz, Jacek
Kubiszewska, Izabela
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to find out if selected lactic acid bacteria (LAB) strains (antagonistic or nonantagonistic against H.
pylori in vitro) would differ in their abilities to modulate the DCs maturation profiles reflected by their phenotype and cytokine expression patterns.
Methods.
Monocyte-derived DCs maturation was elicited by their direct exposure to the LAB strains of L.
rhamnosus 900 or L.
paracasei 915 (antagonistic and nonantagonistic to H.
pylori, resp.), in the presence or absence of H.
pylori strain cagA+.
The DCs maturation profile was assessed on the basis of surface markers expression and cytokines production.
Results.
We observed that the LAB strains and the mixtures of LAB with H.
pylori are able to induce mature DCs.
At the same time, the L.
paracasei 915 leads to high IL-10/IL-12p70 cytokine ratio, in contrast to L.
rhamnosus 900.
Conclusions.
This study showed that the analyzed lactobacilli strains are more potent stimulators of DC maturation than H.
pylori.
Interestingly from the two chosen LAB strains the antagonistic to H.
pylori-L.
rhamnosus strain 900 has more proinflammatory and probably antibactericidal properties.
American Psychological Association (APA)
Wiese, Małgorzata& Eljaszewicz, Andrzej& Helmin-Basa, Anna& Andryszczyk, Marek& Motyl, Ilona& Wieczyńska, Jolanta…[et al.]. 2015. Lactic Acid Bacteria Strains Exert Immunostimulatory Effect on H. pylori-Induced Dendritic Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068356
Modern Language Association (MLA)
Wiese, Małgorzata…[et al.]. Lactic Acid Bacteria Strains Exert Immunostimulatory Effect on H. pylori-Induced Dendritic Cells. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068356
American Medical Association (AMA)
Wiese, Małgorzata& Eljaszewicz, Andrzej& Helmin-Basa, Anna& Andryszczyk, Marek& Motyl, Ilona& Wieczyńska, Jolanta…[et al.]. Lactic Acid Bacteria Strains Exert Immunostimulatory Effect on H. pylori-Induced Dendritic Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068356