Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis
Joint Authors
De Silvestri, Annalisa
Decembrino, Lidia
De Amici, Mara
Pozzi, Margherita
Stronati, Mauro
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
The correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay.
Calprotectin is an antimicrobial, calcium and zinc binding heterocomplex protein that could be used as a nonspecific marker for activation of granulocytes and mononuclear phagocytes.
Calprotectin has been proposed for the diagnosis of inflammatory conditions.
Our aim is to study serum calprotectin as a biomarker for neonatal sepsis diagnosis.
Methods.
41 (20 females, 21 males) infants who underwent blood culture due to suspected sepsis were enrolled in the study.
Serum calprotectin was measured by a commercial ELISA assay (Calprest, Eurospital, Trieste, Italy).
Statistical analysis was performed using the statistical software package Stata 13.1 (Stata Corporation, College Station, Texas, USA).
Results.
8 neonates (19.51%) showed sepsis with positive culture and 33 (80.49%) showed suspected sepsis.
The optimal cut-off for calprotectin is 2.2 μg/mL with a sensitivity of 62.5% and a specificity of 69.7%.
Conclusions.
Calprotectin may be considered a promising early, sensitive, specific marker of sepsis thanks to the importance of calprotectin in defense mechanisms and physiological functions of the immune system.
American Psychological Association (APA)
Decembrino, Lidia& De Amici, Mara& Pozzi, Margherita& De Silvestri, Annalisa& Stronati, Mauro. 2015. Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1068372
Modern Language Association (MLA)
Decembrino, Lidia…[et al.]. Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis. Journal of Immunology Research No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1068372
American Medical Association (AMA)
Decembrino, Lidia& De Amici, Mara& Pozzi, Margherita& De Silvestri, Annalisa& Stronati, Mauro. Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1068372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068372