Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis

Joint Authors

Cardona-Muñoz, Ernesto German
Nava, Arnulfo
Ponce-Guarneros, Manuel
Martínez-García, Erika Aurora
Salazar-Paramo, Mario
Mejía, Mayra
Juárez-Contreras, Pablo
Corona-Sánchez, Esther Guadalupe
Rodríguez-Hernández, Tania Marlen
Gonzalez-Lopez, Laura
Olivas-Flores, Eva Maria
Celis, Alfredo
Vázquez-Del Mercado, Mónica
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel

Source

Journal of Immunology Research

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-19

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Objective.

To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD).

Methods.

In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only).

Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified.

Results.

Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P<0.001).

In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P=0.003) and + RF (P=0.002).

In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P=0.02) and with fibrosis score DD (P=0.01), anti-CCP2 titers (P<0.001), and MTX treatment duration (P<0.001).

Conclusions.

Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT.

Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD.

American Psychological Association (APA)

Rocha-Muñoz, Alberto Daniel& Ponce-Guarneros, Manuel& Gamez-Nava, Jorge Ivan& Olivas-Flores, Eva Maria& Mejía, Mayra& Juárez-Contreras, Pablo…[et al.]. 2015. Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068373

Modern Language Association (MLA)

Rocha-Muñoz, Alberto Daniel…[et al.]. Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068373

American Medical Association (AMA)

Rocha-Muñoz, Alberto Daniel& Ponce-Guarneros, Manuel& Gamez-Nava, Jorge Ivan& Olivas-Flores, Eva Maria& Mejía, Mayra& Juárez-Contreras, Pablo…[et al.]. Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068373

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1068373