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Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis
Joint Authors
Castellano, Lúcio Roberto
Vinícius da Silva, Marcos
Argiro, Laurent
Dessein, Helia
Dessein, Alain
Correia, Dalmo
Rodrigues, Virmondes
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-γ-dependent responses are associated with parasite killing and host protection.
Innovative strategies are needed to overcome therapeutic failure observed in endemic areas.
The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here.
Partial IL-10 blockade in Leishmania braziliensis whole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated.
Overall decrease in IL-10, IL-4, and TNF-α production was observed in all groups of subjects.
Only patients with active lesions still produced some levels of TNF-α after anti-IL-10 stimulation in association with Leishmania antigens.
Moreover, this strategy showed limited modulatory effects on IFN-γ-dependent chemokine CXCL10 production.
Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis.
American Psychological Association (APA)
Castellano, Lúcio Roberto& Argiro, Laurent& Dessein, Helia& Dessein, Alain& Vinícius da Silva, Marcos& Correia, Dalmo…[et al.]. 2015. Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068374
Modern Language Association (MLA)
Castellano, Lúcio Roberto…[et al.]. Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis. Journal of Immunology Research No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1068374
American Medical Association (AMA)
Castellano, Lúcio Roberto& Argiro, Laurent& Dessein, Helia& Dessein, Alain& Vinícius da Silva, Marcos& Correia, Dalmo…[et al.]. Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068374