Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus
Joint Authors
Licciardi, Paul V.
Tsoi, Shu Ki
Smeesters, Pierre R.
Frost, Hannah R. C.
Steer, Andrew C.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases.
It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available.
Progress in GAS vaccine development has been hindered by a number of obstacles, including a lack of standardization in immunoassays and the need to define human correlates of protection.
In this review, we have examined the current immunoassays used in both GAS and other organisms, and explored the various challenges in their implementation in order to propose potential future directions to identify a correlate of protection and facilitate the development of M protein-based vaccines, which are currently the main GAS vaccine candidates.
American Psychological Association (APA)
Tsoi, Shu Ki& Smeesters, Pierre R.& Frost, Hannah R. C.& Licciardi, Paul V.& Steer, Andrew C.. 2015. Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068382
Modern Language Association (MLA)
Tsoi, Shu Ki…[et al.]. Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068382
American Medical Association (AMA)
Tsoi, Shu Ki& Smeesters, Pierre R.& Frost, Hannah R. C.& Licciardi, Paul V.& Steer, Andrew C.. Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068382