Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis
Joint Authors
Dahmen, Uta
Kan, Lixin
Fang, Haoshu
Jiang, Wei
Cheng, Jin
Lu, Yan
Liu, Anding
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sepsis and SIRS (systemic inflammatory response syndrome) belong to a severe disease complex characterized by infection and/or a whole-body inflammatory state.
There is a growing body of evidence that neutrophils are actively involved in sepsis and are responsible for both release of cytokines and phagocytosis of pathogens.
The neutrophil level is mainly regulated by G-CSF, a cytokine and drug, which is widely used in the septic patient with neutropenia.
This review will briefly summarize the role of neutrophils and the therapeutic effect of G-CSF in sepsis.
We further suggest that targeting neutrophil function to modulate the balance between innate immunity and inflammatory injury could be a worthwhile therapeutic strategy for sepsis.
American Psychological Association (APA)
Fang, Haoshu& Jiang, Wei& Cheng, Jin& Lu, Yan& Liu, Anding& Kan, Lixin…[et al.]. 2015. Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068394
Modern Language Association (MLA)
Fang, Haoshu…[et al.]. Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068394
American Medical Association (AMA)
Fang, Haoshu& Jiang, Wei& Cheng, Jin& Lu, Yan& Liu, Anding& Kan, Lixin…[et al.]. Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068394