Pathogenesis of Bone Alterations in Gaucher Disease: The Role of Immune System
Joint Authors
Mucci, Juan Marcos
Rozenfeld, Paula
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gaucher, the most prevalent lysosomal disorder, is an autosomal recessive inherited disorder due to a deficiency of glucocerebrosidase.
Glucocerebrosidase deficiency leads to the accumulation of glucosylceramide primarily in cells of mononuclear-macrophage lineage.
Clinical alterations are visceral, hematological, and skeletal.
Bone disorder in Gaucher disease produces defects on bone metabolism and structure and patients suffer from bone pain and crisis.
Skeletal problems include osteopenia, osteoporosis, osteolytic lesions, and osteonecrosis.
On the other hand a chronic stimulation of the immune system is a well-accepted hallmark in this disease.
In this review we summarize the latest findings in the mechanisms leading to the bone pathology in Gaucher disease in relationship with the proinflammatory state.
American Psychological Association (APA)
Mucci, Juan Marcos& Rozenfeld, Paula. 2015. Pathogenesis of Bone Alterations in Gaucher Disease: The Role of Immune System. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068398
Modern Language Association (MLA)
Mucci, Juan Marcos& Rozenfeld, Paula. Pathogenesis of Bone Alterations in Gaucher Disease: The Role of Immune System. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068398
American Medical Association (AMA)
Mucci, Juan Marcos& Rozenfeld, Paula. Pathogenesis of Bone Alterations in Gaucher Disease: The Role of Immune System. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068398