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Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines
Joint Authors
Preckel, Benedikt
Oei, Gezina Tanya Mei Ling
Aslami, Hamid
Kerindongo, Raphaela Priscilla
Steenstra, Renske Johanna
Beurskens, Charlotte Jacqueline Peter
Tuip-de Boer, Anita Maria
Hollmann, Markus Werner
Weber, Nina Claudia
Juffermans, Nicole P.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Postconditioning of myocardial tissue employs short cycles of ischemia or pharmacologic agents during early reperfusion.
Effects of helium postconditioning protocols on infarct size and the ischemia/reperfusion-induced immune response were investigated by measurement of protein and mRNA levels of proinflammatory cytokines.
Rats were anesthetized with S-ketamine (150 mg/kg) and diazepam (1.5 mg/kg).
Regional myocardial ischemia/reperfusion was induced; additional groups inhaled 15, 30, or 60 min of 70% helium during reperfusion.
Fifteen minutes of helium reduced infarct size from 43% in control to 21%, whereas 30 and 60 minutes of helium inhalation led to an infarct size of 47% and 39%, respectively.
Increased protein levels of cytokine-induced neutrophil chemoattractant (CINC-3) and interleukin-1 beta (IL-1β) were found after 30 or 60 min of helium inhalation, in comparison to control.
30 min of helium increased mRNA levels of CINC-3, IL-1β, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF- α ) in myocardial tissue not directly subjected to ischemia/reperfusion.
These results suggest that the effectiveness of the helium postconditioning protocol is very sensitive to duration of noble gas application.
Additionally, helium was associated with higher levels of inflammatory cytokines; however, it is not clear whether this is causative of nature or part of an epiphenomenon.
American Psychological Association (APA)
Oei, Gezina Tanya Mei Ling& Aslami, Hamid& Kerindongo, Raphaela Priscilla& Steenstra, Renske Johanna& Beurskens, Charlotte Jacqueline Peter& Tuip-de Boer, Anita Maria…[et al.]. 2015. Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068408
Modern Language Association (MLA)
Oei, Gezina Tanya Mei Ling…[et al.]. Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068408
American Medical Association (AMA)
Oei, Gezina Tanya Mei Ling& Aslami, Hamid& Kerindongo, Raphaela Priscilla& Steenstra, Renske Johanna& Beurskens, Charlotte Jacqueline Peter& Tuip-de Boer, Anita Maria…[et al.]. Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068408