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Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases
Joint Authors
Zhang, Yi
Li, Jun
Zhang, Ya-Min
Zhang, Xiao-Ming
Tao, Juan
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL).
TACI is a regulator in the immune responses.
TACI inhibits B cell expansion and promotes the differentiation and survival of plasma cells.
The mechanisms underlying these effects probably involve changed expressions of some crucial molecules, such as B lymphocyte induced maturation protein-1 (Blimp-1) and inducible T-cell costimulator ligand (ICOSL) in B cells and/or plasma cells.
However, abnormal TACI signaling may relate to autoimmune disorders.
Common variable immune deficiency (CVID) patients with heterozygous mutations in TACI alleles increase susceptibility to autoimmune diseases.
Taci−/− mice and BAFF transgenic mice both develop signs of human SLE.
These findings that indicate inappropriate levels of TACI signaling may disrupt immune system balance, thereby promoting the development of autoimmune diseases.
In this review, we summarize the basic characteristics of the TACI ligands BAFF and APRIL, and detail the research findings on the role of TACI in humoral immunity.
We also discuss the possible mechanisms underlying the susceptibility of CVID patients with TACI mutations to autoimmune diseases and the role of TACI in the pathogenesis of SLE.
American Psychological Association (APA)
Zhang, Yi& Li, Jun& Zhang, Ya-Min& Zhang, Xiao-Ming& Tao, Juan. 2015. Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068415
Modern Language Association (MLA)
Zhang, Yi…[et al.]. Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068415
American Medical Association (AMA)
Zhang, Yi& Li, Jun& Zhang, Ya-Min& Zhang, Xiao-Ming& Tao, Juan. Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068415