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Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Joint Authors
Pession, Andrea
Zama, Daniele
Urbini, Milena
Astolfi, Annalisa
Libri, Virginia
Vendemini, Francesca
Morello, William
Rondelli, Roberto
Prete, Arcangelo
Masetti, Riccardo
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Single nucleotide polymorphisms (SNPs) in gene encoding pro- and anti-inflammatory factors have been associated with the occurrence of aGvHD.
We retrospectively tested a wide panel of 38 polymorphisms in 19 immunoregulatory genes, aiming to first establish, in a pediatric HSCT setting, which SNPs were significantly associated with the development of aGvHD.
A significant association was found between aGvHD grades II–IV and SNPs of donor IL10-1082GG, and Fas-670CC + CT and recipient IL18-607 TT + TG genotype.
aGvHD grades III-IV resulted associated with donor IL10-1082GG, Fas-670CC + CT, and TLR4-3612TT as well as the use of peripheral CD34+ cells as stem cell source.
The multivariate analysis confirmed the association between donor IL10-1082GG and Fas-670CC + CT and aGvHD grades II–IV and between donor IL10-1082GG and TLR4-3612TT and aGvHD grades III-IV.
In conclusion we found an association between IL10, FAS, and TLR4 in the donor and IL18 in the recipient and an increased risk of developing aGvHD in transplanted children.
Knowledge of the SNPs of cytokine genes associated with aGvHD represents a useful tool for an integrated pretransplantation risk assessment and could guide the physicians to an optimal and more accurate HSCT planning.
American Psychological Association (APA)
Masetti, Riccardo& Zama, Daniele& Urbini, Milena& Astolfi, Annalisa& Libri, Virginia& Vendemini, Francesca…[et al.]. 2015. Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068416
Modern Language Association (MLA)
Masetti, Riccardo…[et al.]. Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Immunology Research No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1068416
American Medical Association (AMA)
Masetti, Riccardo& Zama, Daniele& Urbini, Milena& Astolfi, Annalisa& Libri, Virginia& Vendemini, Francesca…[et al.]. Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068416