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An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis
Joint Authors
Ramírez-Sandoval, Roxana
Luévano-Rodríguez, Nayeli
Rodríguez-Rodríguez, Mayra
Pérez-Pérez, María Elena
Saldívar-Elias, Sergio
Gurrola-Carlos, Reinaldo
Bollain-y-Goytia, Juan José
Herrera-Esparza, Rafael
Avalos-Díaz, Esperanza
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Autoimmune nephritis triggered by metallic ions was assessed in a Long-Evans rat model.
The parameters evaluated included antinuclear autoantibody production, kidney damage mediated by immune complexes detected by immunofluorescence, and renal function tested by retention of nitrogen waste products and proteinuria.
To accomplish our goal, the animals were treated with the following ionic metals: HgCl2, CuSO4, AgNO3, and Pb(NO3)2.
A group without ionic metals was used as the control.
The results of the present investigation demonstrated that metallic ions triggered antinuclear antibody production in 60% of animals, some of them with anti-DNA specificity.
Furthermore, all animals treated with heavy metals developed toxic glomerulonephritis with immune complex deposition along the mesangium and membranes.
These phenomena were accompanied by proteinuria and increased concentrations of urea.
Based on these results, we conclude that metallic ions may induce experimental autoimmune nephritis.
American Psychological Association (APA)
Ramírez-Sandoval, Roxana& Luévano-Rodríguez, Nayeli& Rodríguez-Rodríguez, Mayra& Pérez-Pérez, María Elena& Saldívar-Elias, Sergio& Gurrola-Carlos, Reinaldo…[et al.]. 2015. An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068426
Modern Language Association (MLA)
Ramírez-Sandoval, Roxana…[et al.]. An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068426
American Medical Association (AMA)
Ramírez-Sandoval, Roxana& Luévano-Rodríguez, Nayeli& Rodríguez-Rodríguez, Mayra& Pérez-Pérez, María Elena& Saldívar-Elias, Sergio& Gurrola-Carlos, Reinaldo…[et al.]. An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068426