Interleukin-23R rs7517847 TG Polymorphism Contributes to the Risk of Crohn’s Disease in Caucasians: A Meta-Analysis
Joint Authors
Lu, Yunjie
Zhang, Li
Ge, Yuzheng
Shi, Yun
Wu, Xing
Xu, Qinghua
Li, Xiaoping
Lu, Ling
Zhang, Feng
Yao, Guozhong
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The association between Interleukin-23R gene polymorphism and Crohn’s disease (CD) in Caucasians is still controversial.
Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk.
We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians.
The significant associations were confirmed between rs7517847 and CD risk in dominant models (TT/TG versus GG: OR = 1.652, 95% CI 1.277, 2.137), allelic model (T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469), homozygote comparison (TT versus GG: OR = 1.890, 95% CI 1.465, 2.437), heterozygote comparison (TG versus GG: OR = 1.509, 95% CI 1.161, 1.960), and recessive model (TT versus TG/GG: OR = 1.409, 95% CI 1.279, 1.552).
In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians.
These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.
American Psychological Association (APA)
Zhang, Li& Lu, Yunjie& Ge, Yuzheng& Shi, Yun& Wu, Xing& Xu, Qinghua…[et al.]. 2015. Interleukin-23R rs7517847 TG Polymorphism Contributes to the Risk of Crohn’s Disease in Caucasians: A Meta-Analysis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068429
Modern Language Association (MLA)
Zhang, Li…[et al.]. Interleukin-23R rs7517847 TG Polymorphism Contributes to the Risk of Crohn’s Disease in Caucasians: A Meta-Analysis. Journal of Immunology Research No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1068429
American Medical Association (AMA)
Zhang, Li& Lu, Yunjie& Ge, Yuzheng& Shi, Yun& Wu, Xing& Xu, Qinghua…[et al.]. Interleukin-23R rs7517847 TG Polymorphism Contributes to the Risk of Crohn’s Disease in Caucasians: A Meta-Analysis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068429