Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells
Joint Authors
Geng, Linyu
Sun, Lingyun
Yao, Genghong
Zhang, Lu
Sun, Yue
Deng, Wei
Liu, Rui
Chen, Weiwei
Zhang, Huayong
Gao, Xiang
Feng, Xuebing
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties and are suggested to be involved in the pathogenesis of immune-related diseases.
This study explored the function of bone marrow MSCs from rheumatoid arthritis (RA) patients, focusing on immunomodulatory effects.
RA MSCs showed decreased proliferative activity and aberrant migration capacity.
No significant differences were observed in cytokine profiles between RA and control MSCs.
The effects of RA MSCs on proliferation of peripheral blood mononuclear cells (PBMCs) and distribution of specific CD4+ T cell subtypes (Th17, Treg, and Tfh cells) were investigated.
RA MSCs appeared to be indistinguishable from controls in suppressing PBMC proliferation, decreasing the proportion of Tfh cells, and inducing the polarization of Treg cells.
However, the capacity to inhibit Th17 cell polarization was impaired in RA MSCs, which was related to the low expression of CCL2 in RA MSCs after coculture with CD4+ T cells.
These findings indicated that RA MSCs display defects in several important biological activities, especially the capacity to inhibit Th17 cell polarization.
These functionally impaired MSCs may contribute to the development of RA disease.
American Psychological Association (APA)
Sun, Yue& Deng, Wei& Geng, Linyu& Zhang, Lu& Liu, Rui& Chen, Weiwei…[et al.]. 2015. Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068432
Modern Language Association (MLA)
Sun, Yue…[et al.]. Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068432
American Medical Association (AMA)
Sun, Yue& Deng, Wei& Geng, Linyu& Zhang, Lu& Liu, Rui& Chen, Weiwei…[et al.]. Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068432