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The Novel PKCθ from Benchtop to Clinic
Joint Authors
Hage-Sleiman, Rouba
Hamze, Asmaa B.
Reslan, Lina
Kobeissy, Hadile
Dbaibo, Ghassan
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The protein kinases C (PKCs) are a family of serine/threonine kinases involved in regulating multiple essential cellular processes such as survival, proliferation, and differentiation.
Of particular interest is the novel, calcium-independent PKCθ which plays a central role in immune responses.
PKCθ shares structural similarities with other PKC family members, mainly consisting of an N-terminal regulatory domain and a C-terminal catalytic domain tethered by a hinge region.
This isozyme, however, is unique in that it translocates to the immunological synapse between a T cell and an antigen-presenting cell (APC) upon T cell receptor-peptide MHC recognition.
Thereafter, PKCθ interacts physically and functionally with downstream effectors to mediate T cell activation and differentiation, subsequently leading to inflammation.
PKCθ-specific perturbations have been identified in several diseases, most notably autoimmune disorders, and hence the modulation of its activity presents an attractive therapeutic intervention.
To that end, many inhibitors of PKCs and PKCθ have been developed and tested in preclinical and clinical studies.
And although selectivity remains a challenge, results are promising for the future development of effective PKCθ inhibitors that would greatly advance the treatment of several T-cell mediated diseases.
American Psychological Association (APA)
Hage-Sleiman, Rouba& Hamze, Asmaa B.& Reslan, Lina& Kobeissy, Hadile& Dbaibo, Ghassan. 2015. The Novel PKCθ from Benchtop to Clinic. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1068448
Modern Language Association (MLA)
Hage-Sleiman, Rouba…[et al.]. The Novel PKCθ from Benchtop to Clinic. Journal of Immunology Research No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1068448
American Medical Association (AMA)
Hage-Sleiman, Rouba& Hamze, Asmaa B.& Reslan, Lina& Kobeissy, Hadile& Dbaibo, Ghassan. The Novel PKCθ from Benchtop to Clinic. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1068448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068448