![](/images/graphics-bg.png)
Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells
Joint Authors
Morales-Montor, Jorge
Nava-Castro, Karen
Muñoz-Cruz, Samira
Mendoza-Rodríguez, Yolanda
Yepez-Mulia, Lilián
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mast cells (MCs) are versatile effector and regulatory cells in various physiologic, immunologic, and pathologic processes.
In addition to the well-characterized IgE/FcεRI-mediated degranulation, a variety of biological substances can induce MCs activation and release of their granule content.
Sex steroids, mainly estradiol and progesterone, have been demonstrated to elicit MCs activation.
Most published studies have been conducted on MCs lines or freshly isolated peritoneal and bone marrow-derived MC without addressing gender impact on MC response.
Our goal was to investigate if the effect of estradiol, progesterone, testosterone, and dihydrotestosterone (DHT) on MCs may differ depending on whether female or male rats are used as MCs donors.
Our results demonstrated that effect of sex steroids on MCs histamine release is dose- and gender-dependent and can be direct, synergistic, or inhibitory depending on whether hormones are used alone or to pretreat MCs followed by substance P-stimulation or upon IgE-mediated stimulation.
In contrast, sex steroids did not have effect on the MC expression of the IgE high affinity receptor, FcεRI, no matter female or male rats were used.
In conclusion, MCs degranulation is modulated by sex hormones in a gender-selective fashion, with MC from females being more susceptible than MC from males to the effects of sex steroids.
American Psychological Association (APA)
Muñoz-Cruz, Samira& Mendoza-Rodríguez, Yolanda& Nava-Castro, Karen& Yepez-Mulia, Lilián& Morales-Montor, Jorge. 2015. Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068449
Modern Language Association (MLA)
Muñoz-Cruz, Samira…[et al.]. Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068449
American Medical Association (AMA)
Muñoz-Cruz, Samira& Mendoza-Rodríguez, Yolanda& Nava-Castro, Karen& Yepez-Mulia, Lilián& Morales-Montor, Jorge. Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068449