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Immunomodulatory Effects Mediated by Serotonin
Joint Authors
Hurtado-Alvarado, Gabriela
Quintero-Fabián, Saray
Becerril, Enrique
Velasco-Velázquez, Marco Antonio
Arreola, Rodrigo
Cruz-Fuentes, Carlos
Garcés-Alvarez, María Eugenia
Pavon, Lenin
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Serotonin (5-HT) induces concentration-dependent metabolic effects in diverse cell types, including neurons, entherochromaffin cells, adipocytes, pancreatic beta-cells, fibroblasts, smooth muscle cells, epithelial cells, and leukocytes.
Three classes of genes regulating 5-HT function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-HT, such as SERT, 5HTR-GPCR, and the 5HT3-ion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-HT metabolism, such as IDO and MAO, which can generate biologically active catabolites, including melatonin, kynurenines, and kynurenamines.
This review covers the clinical and experimental mechanisms involved in 5-HT-induced immunomodulation.
These mechanisms are cell-specific and depend on the expression of serotonergic components in immune cells.
Consequently, 5-HT can modulate several immunological events, such as chemotaxis, leukocyte activation, proliferation, cytokine secretion, anergy, and apoptosis.
The effects of 5-HT on immune cells may be relevant in the clinical outcome of pathologies with an inflammatory component.
Major depression, fibromyalgia, Alzheimer disease, psoriasis, arthritis, allergies, and asthma are all associated with changes in the serotonergic system associated with leukocytes.
Thus, pharmacological regulation of the serotonergic system may modulate immune function and provide therapeutic alternatives for these diseases.
American Psychological Association (APA)
Arreola, Rodrigo& Becerril, Enrique& Cruz-Fuentes, Carlos& Velasco-Velázquez, Marco Antonio& Garcés-Alvarez, María Eugenia& Hurtado-Alvarado, Gabriela…[et al.]. 2015. Immunomodulatory Effects Mediated by Serotonin. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1068452
Modern Language Association (MLA)
Arreola, Rodrigo…[et al.]. Immunomodulatory Effects Mediated by Serotonin. Journal of Immunology Research No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1068452
American Medical Association (AMA)
Arreola, Rodrigo& Becerril, Enrique& Cruz-Fuentes, Carlos& Velasco-Velázquez, Marco Antonio& Garcés-Alvarez, María Eugenia& Hurtado-Alvarado, Gabriela…[et al.]. Immunomodulatory Effects Mediated by Serotonin. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1068452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068452