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Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis
Joint Authors
Hair-Bejo, Mohd
Bande, Faruku
Arshad, Siti Suri
Moeini, Hassan
Omar, Abdul Rahman
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry.
The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge.
Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage.
On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens.
Consequently, alternative IB vaccines are widely sought.
Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines.
Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches.
Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.
American Psychological Association (APA)
Bande, Faruku& Arshad, Siti Suri& Hair-Bejo, Mohd& Moeini, Hassan& Omar, Abdul Rahman. 2015. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068473
Modern Language Association (MLA)
Bande, Faruku…[et al.]. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068473
American Medical Association (AMA)
Bande, Faruku& Arshad, Siti Suri& Hair-Bejo, Mohd& Moeini, Hassan& Omar, Abdul Rahman. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068473