Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149GT
Joint Authors
Word, Beverly
Tolleson, William H.
Treadwell, Edward L.
Wiley, Kenneth
Melchior, William
Gopee, Neera
Hammons, George
Lyn-Cook, Beverly
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) has shown an association with high levels of prolactin, low levels of dehydroepiandrosterone (DHEA), and induction of inflammatory cytokines in the serum of patients with the disease.
This preliminary study examined the relevance of a −1149G/T functional single-nucleotide polymorphism (SNP) (rs1341239) in the promoter of the extrapituitary prolactin gene in a cohort of African American and European American women with lupus.
Examination of this SNP revealed that the −1149TT genotype was correlated with higher levels of prolactin in serum and prolactin gene expression (p=0.0001) in peripheral blood mononuclear cells (PBMCs).
Lower levels of DHEA in serum were demonstrated in lupus patients (p=0.001); those with the −1149TT genotype had the lowest levels of DHEA.
Furthermore, a small subset of women who were on DHEA therapy and had a TT genotype showed a significant decrease in prolactin gene expression and lower disease activity scores (SLEDAI).
Lupus patients, particularly African Americans, had significantly higher levels of IL-6 (p=0.0001) and TNF-α (p=0.042).
This study suggests that the −1149TT genotype may be a risk factor for lupus and may predict who could possibly benefit from DHEA therapy; therefore, these results should be validated in a larger cohort with all ethnic groups.
American Psychological Association (APA)
Treadwell, Edward L.& Wiley, Kenneth& Word, Beverly& Melchior, William& Tolleson, William H.& Gopee, Neera…[et al.]. 2015. Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149GT. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068478
Modern Language Association (MLA)
Treadwell, Edward L.…[et al.]. Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149GT. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068478
American Medical Association (AMA)
Treadwell, Edward L.& Wiley, Kenneth& Word, Beverly& Melchior, William& Tolleson, William H.& Gopee, Neera…[et al.]. Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149GT. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068478