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Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer’s Disease
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response.
On the other hand, neuroinflammation is strongly implicated in Alzheimer’s disease (AD), which can be enhanced by systemic inflammation, such as that due to cardiovascular disease and diabetes.
There is growing clinical evidence supporting the concept that rheumatoid arthritis and periodontitis are positively linked to AD, suggesting that inflammatory bone disorders are risk factors for this condition.
Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to brain-resident microglia.
More importantly, senescent-type, but not juvenile-type, microglia provoke neuroinflammation in response to systemic inflammation.
Because the prevalence of rheumatoid arthritis and periodontitis increases with age, inflammatory bone disorders may be significant sources of covert systemic inflammation among elderly people.
The present review article highlights our current understanding of the link between inflammatory bone disorders and AD with a special focus on microglia aging.
American Psychological Association (APA)
Wu, Zhou& Nakanishi, Hiroshi. 2015. Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer’s Disease. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068483
Modern Language Association (MLA)
Wu, Zhou& Nakanishi, Hiroshi. Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer’s Disease. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068483
American Medical Association (AMA)
Wu, Zhou& Nakanishi, Hiroshi. Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer’s Disease. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068483