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NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML
Joint Authors
Lang, Peter
Schlegel, Patrick
Ditthard, Kerstin
Michaelis, Sebastian
Pfeiffer, Matthias
Handgretinger, Rupert
Mezger, Markus
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Natural killer cells have been shown to be relevant in the recognition and lysis of acute myeloid leukemia.
In childhood acute lymphoblastic leukemia, it was shown that HLA I expression and KIR receptor-ligand mismatch significantly impact ALL cytolysis.
We characterized 14 different primary childhood AML blasts by flow cytometry including NKG2D ligands.
Further HLA I typing of blasts was performed and HLA I on the AML blasts was quantified.
In two healthy volunteer NK cell donors HLA I typing and KIR genotyping were done.
Blasts with high NKG2D ligand expression had significantly higher lysis by isolated NK cells.
Grouping the blasts by NKG2D ligand expression led to a significant inverse correlation of HLA I expression and cytolysis in NKG2D low blasts.
Furthermore, a significant positive correlation of NKG2D ligand expression and blast cytolysis was shown.
No impact of KIR ligand-ligand mismatch was found but a significantly increased lysis of homozygous C2 blasts by KIR2DL1 negative NK cells (donor B) was revealed.
In conclusion, NKG2D signaling leads to NK cell mediated lysis of childhood AML despite high HLA I expression.
American Psychological Association (APA)
Schlegel, Patrick& Ditthard, Kerstin& Lang, Peter& Mezger, Markus& Michaelis, Sebastian& Handgretinger, Rupert…[et al.]. 2015. NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068484
Modern Language Association (MLA)
Schlegel, Patrick…[et al.]. NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068484
American Medical Association (AMA)
Schlegel, Patrick& Ditthard, Kerstin& Lang, Peter& Mezger, Markus& Michaelis, Sebastian& Handgretinger, Rupert…[et al.]. NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068484