Innate Immune Memory: The Latest Frontier of Adjuvanticity
Joint Authors
Töpfer, Elfi
Boraschi, Diana
Italiani, Paola
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent findings in the field of immune memory have demonstrated that B and T cell mediated immunity following infections are enhanced by the so-called trained immunity.
This effect has been most extensively investigated for the tuberculosis vaccine strain Bacillus Calmette-Guérin (BCG).
Epidemiological studies suggest that this vaccine is associated with a substantial reduction in overall child mortality that cannot be solely explained by prevention of the target disease but that it seems to rely on inducing resistance to other infections.
Upon infection or vaccination, monocytes/macrophages can be functionally reprogrammed so as to display an enhanced defensive response against unrelated infections.
Epigenetic modifications seem to play a key role in the induction of this “innate memory.” These findings are revolutionising our knowledge of the immune system, introducing the concept of memory also for mammalian innate immunity.
Thus, vaccines are likely to nonspecifically affect the overall immunological status of individuals in a clinically relevant manner.
As a consequence, future vaccine strategies ought to take into account the contribution of innate memory through appropriate design of formulations and administration scheduling.
American Psychological Association (APA)
Töpfer, Elfi& Boraschi, Diana& Italiani, Paola. 2015. Innate Immune Memory: The Latest Frontier of Adjuvanticity. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068486
Modern Language Association (MLA)
Töpfer, Elfi…[et al.]. Innate Immune Memory: The Latest Frontier of Adjuvanticity. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068486
American Medical Association (AMA)
Töpfer, Elfi& Boraschi, Diana& Italiani, Paola. Innate Immune Memory: The Latest Frontier of Adjuvanticity. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068486