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The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes
Joint Authors
Górski, Andrzej
Jończyk-Matysiak, Ewa
Kłak, Marlena
Weber-Dąbrowska, Beata
Łusiak-Szelachowska, Marzanna
Bubak, Barbara
Międzybrodzki, Ryszard
Żaczek, Maciej
Fortuna, Wojciech
Rogóż, Paweł
Letkiewicz, Sławomir
Szufnarowski, Krzysztof
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Intracellular killing of bacteria is one of the fundamental mechanisms against invading pathogens.
Impaired intracellular killing of bacteria by phagocytes may be the reason of chronic infections and may be caused by antibiotics or substances that can be produced by some bacteria.
Therefore, it was of great practical importance to examine whether phage preparations may influence the process of phagocyte intracellular killing of bacteria.
It may be important especially in the case of patients qualified for experimental phage therapy (approximately half of the patients with chronic bacterial infections have their immunity impaired).
Our analysis included 51 patients with chronic Gram-negative and Gram-positive bacterial infections treated with phage preparations at the Phage Therapy Unit in Wroclaw.
The aim of the study was to investigate the effect of experimental phage therapy on intracellular killing of bacteria by patients’ peripheral blood monocytes and polymorphonuclear neutrophils.
We observed that phage therapy does not reduce patients’ phagocytes’ ability to kill bacteria, and it does not affect the activity of phagocytes in patients with initially reduced ability to kill bacteria intracellularly.
Our results suggest that experimental phage therapy has no significant adverse effects on the bactericidal properties of phagocytes, which confirms the safety of the therapy.
American Psychological Association (APA)
Jończyk-Matysiak, Ewa& Łusiak-Szelachowska, Marzanna& Kłak, Marlena& Bubak, Barbara& Międzybrodzki, Ryszard & Weber-Dąbrowska, Beata…[et al.]. 2015. The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068491
Modern Language Association (MLA)
Jończyk-Matysiak, Ewa…[et al.]. The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068491
American Medical Association (AMA)
Jończyk-Matysiak, Ewa& Łusiak-Szelachowska, Marzanna& Kłak, Marlena& Bubak, Barbara& Międzybrodzki, Ryszard & Weber-Dąbrowska, Beata…[et al.]. The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068491