Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients
Joint Authors
Park, Sung-Hwan
Lee, Sang Jin
Park, Won
Shim, Seung-Cheol
Baek, Han Joo
Kim, Hyun Ah
Lee, Soo Kon
Leee, Yun Jong
Park, Young Eun
Cha, Hoon-Suk
Park, Jin Kyun
Lee, Eun Young
Lee, Eun Bong
Song, Yeong Wook
Yoo, Dae-Hyun
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
T helper 17-related cytokines have been implicated in rheumatoid arthritis (RA) pathogenesis.
The study aimed to identify cytokines associated with the treatment response of RA patients to tocilizumab (TCZ), a humanized monoclonal antibody against the interleukin- (IL-) 6 receptor.
As an independent substudy of the 24-week, randomized, double-blinded CWP-TCZ301 trial of TCZ in RA patients with an inadequate response to disease-modifying antirheumatic drugs, serum levels of cytokines including tumor necrosis factor-alpha, IL-17A, IL-21, IL-23, IL-6, and soluble IL-6 receptor were measured.
Baseline IL-17A levels were significantly lower in RA patients who achieved disease activity score 28 (DAS28) remission at 12 weeks of TCZ treatment, compared to patients not in remission.
Patients were stratified into IL-17A low group and IL-17A high group.
Significantly more patients in the IL-17A low group achieved remission as compared to the IL-17A high group (47.6 versus 17.4%, P=0.032).
DAS28 improvement was significantly better in the IL-17A low group than in the IL-17A high group at 12 weeks (P=0.045) and 24 weeks (P=0.046) after adjustment.
Other baseline cytokines were not associated with treatment response to TCZ.
The data demonstrate that low baseline IL-17A levels are associated with better clinical response to TCZ treatment in RA patients.
American Psychological Association (APA)
Lee, Sang Jin& Park, Won& Park, Sung-Hwan& Shim, Seung-Cheol& Baek, Han Joo& Yoo, Dae-Hyun…[et al.]. 2015. Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068493
Modern Language Association (MLA)
Lee, Sang Jin…[et al.]. Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068493
American Medical Association (AMA)
Lee, Sang Jin& Park, Won& Park, Sung-Hwan& Shim, Seung-Cheol& Baek, Han Joo& Yoo, Dae-Hyun…[et al.]. Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068493