Sepsis: From Pathophysiology to Individualized Patient Care
Joint Authors
Molnar, Zsolt
Trásy, Domonkos
László, Ildikó
Fazakas, János
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together.
Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-large very disappointing.
This fiasco can be explained by several factors, but one of the most important reasons is the uncertain definition of sepsis resulting in very heterogeneous patient populations, and the lack of understanding of pathophysiology, which is mainly based on the imbalance in the host-immune response.
However, this heroic research work has not been in vain.
Putting the results of positive and negative studies into context, we can now approach sepsis in a different concept, which may lead us to new perspectives in diagnostics and treatment.
While decision making based on conventional sepsis definitions can inevitably lead to false judgment due to the heterogeneity of patients, new concepts based on currently gained knowledge in immunology may help to tailor assessment and treatment of these patients to their actual needs.
Summarizing where we stand at present and what the future may hold are the purpose of this review.
American Psychological Association (APA)
László, Ildikó& Trásy, Domonkos& Molnar, Zsolt& Fazakas, János. 2015. Sepsis: From Pathophysiology to Individualized Patient Care. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068502
Modern Language Association (MLA)
László, Ildikó…[et al.]. Sepsis: From Pathophysiology to Individualized Patient Care. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068502
American Medical Association (AMA)
László, Ildikó& Trásy, Domonkos& Molnar, Zsolt& Fazakas, János. Sepsis: From Pathophysiology to Individualized Patient Care. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068502