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Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer
Joint Authors
Wang, Denong
Tang, Jin
Liu, Shaoyi
Huang, Jaoti
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Using carbohydrate microarrays, we explored potential natural ligands of antitumor monoclonal antibody HAE3.
This antibody was raised against a murine mammary tumor antigen but was found to cross-react with a number of human epithelial tumors in tissues.
Our carbohydrate microarray analysis reveals that HAE3 is specific for an O-glycan cryptic epitope that is normally hidden in the cores of blood group substances.
Using HAE3 to screen tumor cell surface markers by flow cytometry, we found that the HAE3 glycoepitope, gpHAE3, was highly expressed by a number of human breast cancer cell lines, including some triple-negative cancers that lack the estrogen, progesterone, and Her2/neu receptors.
Taken together, we demonstrate that HAE3 recognizes a conserved cryptic glycoepitope of blood group precursors, which is nevertheless selectively expressed and surface-exposed in certain breast tumor cells.
The potential of this class of O-glycan cryptic antigens in breast cancer subtyping and targeted immunotherapy warrants further investigation.
American Psychological Association (APA)
Wang, Denong& Tang, Jin& Liu, Shaoyi& Huang, Jaoti. 2015. Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068503
Modern Language Association (MLA)
Wang, Denong…[et al.]. Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068503
American Medical Association (AMA)
Wang, Denong& Tang, Jin& Liu, Shaoyi& Huang, Jaoti. Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068503