SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis
Joint Authors
Saare, Mario
Hämarik, Uku
Venta, Rainis
Panarina, Marina
Zucchelli, Chiara
Pihlap, Maire
Remm, Anu
Kisand, Kai
Toots, Urve
Möll, Kaidi
Salupere, Riina
Musco, Giovanna
Peterson, Pärt
Uibo, Raivo
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The SP100 family members comprise a set of closely related genes on chromosome 2q37.1.
The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases.
Here, we have characterized the SP100 family member SP140L.
The genome sequence analysis showed the formation of SP140L gene through rearrangements of the two neighboring genes, SP100 and SP140, during the evolution of higher primates.
The SP140L expression is interferon-inducible with high transcript levels in B cells and other peripheral blood mononuclear cells.
Subcellularly, SP140L colocalizes with SP100 and SP140 in nuclear structures that are devoid of SP110, PML, or p300 proteins.
Similarly to SP100 and SP140 protein, we detected serum autoantibodies to SP140L in patients with primary biliary cirrhosis using luciferase immunoprecipitation system and immunoblotting assays.
In conclusion, our results show that SP140L is phylogenetically recent member of SP100 proteins and acts as an autoantigen in primary biliary cirrhosis patients.
American Psychological Association (APA)
Saare, Mario& Hämarik, Uku& Venta, Rainis& Panarina, Marina& Zucchelli, Chiara& Pihlap, Maire…[et al.]. 2015. SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068507
Modern Language Association (MLA)
Saare, Mario…[et al.]. SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis. Journal of Immunology Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1068507
American Medical Association (AMA)
Saare, Mario& Hämarik, Uku& Venta, Rainis& Panarina, Marina& Zucchelli, Chiara& Pihlap, Maire…[et al.]. SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068507