Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development
Joint Authors
Hoshino, Yoshihiko
Suzuki, Koichi
Suzukawa, Maho
Ohta, Ken
Niki, Mamiko
Akashi, Shunsuke
Inoue, Manabu
Niki, Makoto
Kaneko, Yukihiro
Morimoto, Kozo
Kitada, Seigo
Matsumoto, Sohkichi
Nagai, Hideaki
Kurashima, Atsuyuki
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Although tuberculosis remains a major global health problem, Bacille Calmette-Guérin (BCG) is the only available vaccine.
However, BCG has limited applications, and a more effective vaccine is needed.
Cellular mediated immunity (CMI) is thought to be the most important immune response for protection against Mycobacterium tuberculosis (Mtb).
However, the recent failure of a clinical trial for a booster BCG vaccine and increasing evidence of antibody-mediated immunity prompted us to evaluate humoral immunity to Mtb-specific antigens.
Using Enzyme-Linked ImmunoSpot and Enzyme-Linked ImmunoSorbent Assays, we observed less correlation of both CMI and IgG titers with patient clinical status, including serum concentration of C reactive protein.
However, IgA titers against Mtb were significantly correlated with clinical status, suggesting that specific IgA antibodies protect against Mtb proliferation.
In addition, in some cases, IgA antibody titers were significantly associated with the serum concentration of total albumin, which supports the idea that humoral immunity can be influenced by the nutritional status.
Based on these observations, we propose that the induction of humoral immunity should be included as an option in TB vaccine development strategies.
American Psychological Association (APA)
Niki, Mamiko& Suzukawa, Maho& Akashi, Shunsuke& Nagai, Hideaki& Ohta, Ken& Inoue, Manabu…[et al.]. 2015. Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068508
Modern Language Association (MLA)
Niki, Mamiko…[et al.]. Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068508
American Medical Association (AMA)
Niki, Mamiko& Suzukawa, Maho& Akashi, Shunsuke& Nagai, Hideaki& Ohta, Ken& Inoue, Manabu…[et al.]. Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068508