Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis
Joint Authors
Sun, Chuan-Yin
Chen, Weiqian
Lin, Jin
Cao, Heng
Xu, Danyi
Xu, Bei
Xu, Liqin
Yue, Lihuan
Wu, Guolin
Qian, Wenbin
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The activated NF-κB signaling pathway plays an important role in pathogenesis of primary Sjögren’s syndrome (pSS).
The inhibitor of κB (IκB) kinase (IKK) family such as IKKα, IKKβ, IKKγ, and IKKε, is required for this signaling.
Our aim was to investigate the role of IKKα/β/γ/ε in patients with untreated pSS.
In minor salivary glands from pSS patients, phosphorylated IKKε (pIKKε), pIκBα, and pNF-κB p65 (p-p65) were highly expressed in ductal epithelium and infiltrating mononuclear cells by immunohistochemistry, compared to healthy individuals.
pIKKα/β and pIKKγ were both negative.
And pIKKε positively related to expression of p-p65.
Furthermore, pIKKε and p-p65 expression significantly correlated with biopsy focus score and overall disease activity.
Meanwhile, in peripheral blood mononuclear cells from pSS patients, pIKKε, total IKKε, pIKKα/β, and p-p65 were significantly increased by western blot, compared to healthy controls.
However, there was no difference in IKKγ and IκBα between pSS patients and healthy individuals.
These results demonstrated an abnormality of IKKε, IκBα, and NF-κB in pSS, suggesting a potential target of treatment for pSS based on the downregulation of IKKε expression and deregulation of NF-κB pathway.
American Psychological Association (APA)
Chen, Weiqian& Lin, Jin& Cao, Heng& Xu, Danyi& Xu, Bei& Xu, Liqin…[et al.]. 2015. Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068512
Modern Language Association (MLA)
Chen, Weiqian…[et al.]. Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068512
American Medical Association (AMA)
Chen, Weiqian& Lin, Jin& Cao, Heng& Xu, Danyi& Xu, Bei& Xu, Liqin…[et al.]. Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068512