Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China
Joint Authors
Wang, Li
Chen, Hua
Zhang, Yao
Liu, Wanli
Zheng, Wenjie
Zhang, Xuan
Zhang, Fengchun
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Clinical characteristics of systemic lupus erythematosus (SLE) patients complicated with cerebral venous sinus thrombosis (CVST) between 2000 and 2013 were analyzed through this retrospective, single-centre study.
Of 4747 hospitalized SLE patients, 17 (0.36%, 12 females, average age 30) had CVST.
Headache (88.2%) was the most common neurological symptom followed by nausea or vomiting (47.1%), conscious disturbance (41.2%), edema of eyelids or conjunctiva (35.3%), blurred vision or diplopia (35.3%), and seizure (35.3%).
Increased intracranial pressure (ICP) occurred in 13 cases (76.5%).
Magnetic resonance venography (MRV) detected thrombosis in the transverse (82.4%), sigmoid (52.9%), and sagittal (35.3%) sinuses, with frequent (70.6%) multiple sinus occlusions.
Compared to SLE patients without CVST, SLE patients with CVST had a higher prevalence of thrombocytopenia and positive antiphospholipid antibodies and a higher SLE disease activity index (SLEDAI) score.
13 patients achieved improvement following glucocorticoids and immunosuppressants treatment, as well as anticoagulants, while 3 patients died at the hospital.
CVST is relatively rare in SLE and tends to occur in active lupus patients.
Intracranial hypertension is common but nonspecific clinical feature, so MRV evaluation is necessary to establish a diagnosis.
Aggressive treatment for the rapid control of SLE activity combined with anticoagulants can improve the prognosis.
American Psychological Association (APA)
Wang, Li& Chen, Hua& Zhang, Yao& Liu, Wanli& Zheng, Wenjie& Zhang, Xuan…[et al.]. 2015. Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068514
Modern Language Association (MLA)
Wang, Li…[et al.]. Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068514
American Medical Association (AMA)
Wang, Li& Chen, Hua& Zhang, Yao& Liu, Wanli& Zheng, Wenjie& Zhang, Xuan…[et al.]. Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068514