![](/images/graphics-bg.png)
New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells
Joint Authors
Caturegli, Patrizio
Kimura, Hiroaki
Suzuki, Koichi
Takahashi, M.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The immunoproteasome is a highly efficient proteolytic machinery derived from the constitutive proteasome and is abundantly expressed in immune cells.
The immunoproteasome plays a critical role in the immune system because it degrades intracellular proteins, for example, those of viral origin, into small proteins.
They are further digested into short peptides to be presented by major histocompatibility complex (MHC) class I molecules.
In addition, the immunoproteasome influences inflammatory disease pathogenesis through its ability to regulate T cell polarization.
The immunoproteasome is also expressed in nonimmune cell types during inflammation or neoplastic transformation, supporting a role in the pathogenesis of autoimmune diseases and neoplasms.
Following the success of inhibitors of the constitutive proteasome, which is now an established treatment modality for multiple myeloma, compounds that selectively inhibit the immunoproteasome are currently under active investigation.
This paper will review the functions of the immunoproteasome, highlighting areas where novel pharmacological treatments that regulate immunoproteasome activity could be developed.
American Psychological Association (APA)
Kimura, Hiroaki& Caturegli, Patrizio& Takahashi, M.& Suzuki, Koichi. 2015. New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068516
Modern Language Association (MLA)
Kimura, Hiroaki…[et al.]. New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068516
American Medical Association (AMA)
Kimura, Hiroaki& Caturegli, Patrizio& Takahashi, M.& Suzuki, Koichi. New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068516